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Test Code vWP von Willebrand Panel

Aliases

von Willebrand Disease Profile 

Useful For

Detection of deficiency or abnormality of von Willebrand factor (VWF) and related deficiency of factor VIII coagulant activity. 

Subtyping von Willebrand disease (VWD) as type 1 (most common), type 2 variants (less common), or type 3 (rare). 

Patient Preparation

Patient should not be receiving anticoagulant treatment (eg, warfarin, heparin). 

Patient should also not be receiving fibrinolytic agents (streptokinase, urokinase, tissue plasminogen activator: tPA). 

If patient has been recently transfused, it is best to perform this study pretransfusion, if possible. 

Special Collection Instructions

Specimen must be collected prior to factor replacement therapy. 

Properly filled 9:1 ratio (blood to anticoagulant); 3.2% NaCitrate 

Collection Method

Venous Draw

Container

Light-blue top (3.2% sodium citrate) 

Preferred Specimen

2.7mL Lt. Blue (3.2% NaCitrate) 

Acceptable Specimens

1.8 mL Lt. Blue (3.2% NaCitrate) tube

Reference or Target Ranges

Normal: 

von Willebrand Factor Activity: 48.8 - 163.4% 

von Willebrand Factor Antigen: 66.1 - 176.3% 

Factor VIII: 50 - 150% 

Reportable Units

% (percentage)

Reasons for Rejection

Hemolysis Threshold Visable unacceptable
Icterus Threshold Visable unacceptable
Lipemia Threshold Visable unacceptable
Interfering Subtances/Other

Short draws, over draws, clotted, improperly labeled, or samples > 4 hours from collection

Specimen Stability

Ambient Plasma – 4 hours
Refrigerated (4°C to 8°C) N/A
Frozen(-70°C to -20°C) 2 weeks@ -20°C; 1 year @ -70°C

Performance Information

Days and Time Performed Batched daily Monday - Friday
Expected Turn Around Time Batched Monday – Friday
Stat Availability No
Performing Bench Coagulation
Methodology/Method Description Werfen ACL TOPS - Latex Immunoturbidimetric Assay

Panel Components

von Willebrand Factor Activity 

von Willebrand Factor Antigen 

Factor VIII 

Additional follow-up tests per guidelines

Pathologist Interpretation

CPT Codes

85245, 85246, 85240, 83590 26

Additional Information / Important Notes

Patients with any of these (Intermediate or high probability):

  • Abnormal personal bleeding history or event
  • Abnormal aPTT result
  • Known first-degree relative with VWD

Recommendation: Proceed with VWD Profile order.

 

For all other patients:  please complete the Bleeding Assessment Tool. Guidelines recommend proceeding with VWD profile testing only if the score is abnormal.

https://bleedingscore.certe.nl/