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HelpTest Code QUAD1 Quad Screen (Second Trimester) Maternal, Serum
Necessary Information
In order to provide the best results, either answer the order entry questions or provide the required information using the Second Trimester Maternal Screening Alpha-Fetoprotein / Quad Screen Patient Information (T595).
Specimen Required
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Do not collect specimen after amniocentesis as this could affect results.
2. Centrifuge and aliquot serum into plastic vial within 2 hours of collection
Additional Information:
1. For an assessment that includes neural tube defect results, gestational age must be between 15 weeks, 0 days and 22 weeks, 6 days.
2. Assessments for trisomy 21 (Down syndrome) and trisomy 18 (Edwards syndrome) only are available between 14 weeks, 0 days and 22 weeks, 6 days.
3. Initial or repeat testing is determined in the laboratory at the time of report and will be reported accordingly. To be considered a repeat test for the patient, the testing must be within the same pregnancy and trimester, with interpretable results for the same tests, and both tests are performed at Mayo Clinic.
4. Maternal Serum Screening patient education brochure (T522) is available upon request.
Forms
Second Trimester Maternal Screening Alpha-Fetoprotein / Quad Screen Patient Information (T595) is required.
Secondary ID
113145Useful For
Prenatal screening for open neural tube defect (alpha-fetoprotein only), trisomy 21 (alpha-fetoprotein, human chorionic gonadotropin, estriol, and inhibin A) and trisomy 18 (alpha-fetoprotein, human chorionic gonadotropin, and estriol)
Special Instructions
Method Name
Immunoenzymatic Assay
Reporting Name
QUAD SCRN (2nd Tri) Maternal, SSpecimen Type
SerumSpecimen Minimum Volume
0.75 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 7 days | |
| Frozen | 90 days | ||
| Ambient | 7 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
NEURAL TUBE DEFECTS:
An alpha-fetoprotein (AFP) multiple of the median (MoM) <2.5 is reported as screen negative.
AFP MoM ≥2.5 (singleton and twin pregnancies) are reported as screen positive.
DOWN SYNDROME:
Calculated screen risks <1/270 are reported as screen negative, risks ≥1/270 are reported as screen positive.
TRISOMY 18:
Calculated screen risks <1/100 are reported as screen negative, risks ≥1/100 are reported as screen positive.
An interpretive report will be provided.
Day(s) Performed
Monday through Friday
Report Available
4 to 6 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
81511
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| QUAD1 | QUAD SCRN (2nd Tri) Maternal, S | 48800-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 7058 | Recalculated Maternal Serum Screen | 32399-8 |
| 113146 | Results Summary | 32399-8 |
| 10334 | Down syndrome screen risk estimate | 43995-0 |
| 10335 | Down syndrome maternal age risk | 49090-4 |
| 10337 | Trisomy 18 screen risk estimate | 43994-3 |
| 113147 | Neural tube defect risk estimate | 48803-1 |
| 10351 | AFP | 83073-7 |
| 113148 | AFP MoM | 23811-3 |
| 601921 | AFP MoM (14,0-14,6) | 23811-3 |
| 10352 | uE3 | 2250-9 |
| 113149 | uE3 MoM | 21264-7 |
| 10353 | hCG, TOTAL | 83086-9 |
| 113150 | hCG, TOTAL MoM | 23841-0 |
| 113151 | INHIBIN MoM | 36904-1 |
| 10354 | INHIBIN | 2478-6 |
| 10356 | INTERPRETATION | 49092-0 |
| 10357 | RECOMMENDED FOLLOW UP | 80615-8 |
| 10248 | Additional comments | 48767-8 |
| 3009 | Specimen collection date | 33882-2 |
| 7823 | Maternal date of birth | 21112-8 |
| 7834 | Calculated age at EDD | 43993-5 |
| 26717 | Maternal Weight | 29463-7 |
| 26718 | Maternal Weight | 29463-7 |
| IDD | Insulin dependent diabetes | 44877-9 |
| RACE1 | Patient race | 21484-1 |
| SMKNG | Current cigarette smoking status | 64234-8 |
| 10054 | EDD by U/S scan | 11781-2 |
| 7203 | GA on collection by U/S scan | 11888-5 |
| 7753 | EDD by LMP | 11779-6 |
| 7204 | GA on collection by dates | 11885-1 |
| 7830 | GA used in risk estimate | 21299-3 |
| MULTF | Number of Fetuses | 55281-0 |
| CHOR_ | Number of Chorions | 92568-5 |
| IVFP | IVF pregnancy | 47224-1 |
| PRHIS | Prev Down (T21) / Trisomy Pregnancy | 53826-4 |
| PRNTD | Prev Pregnancy w/ Neural Tube Defect | 53827-2 |
| PTNTD | Patient or father of baby has a NTD | 53827-2 |
| INTL | Initial or repeat testing | 77202-0 |
| DRPHN | Physician Phone Number | 68340-9 |
| 10358 | GENERAL TEST INFORMATION | 62364-5 |