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HelpTest Code BCGRV Immunoglobulin Gene Rearrangement, PCR, Varies
Reporting Name
Immunoglobulin Gene Rearrange, VUseful For
Determining whether a B-cell or plasma cell population is polyclonal or monoclonal in specimens other than blood or bone marrow
Identifying neoplastic cells as having B-cell or plasma cell differentiation
Monitoring for a persistent neoplasm by detecting an immunoglobulin gene rearrangement profile similar to that from a previous neoplastic specimen
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
VariesShipping Instructions
Body fluid or spinal fluid must arrive within 4 days of collection.
Specimen Required
Submit only 1 of the following specimens:
Specimen Type: Body fluid
Container/Tube: Sterile container
Specimen Volume: At least 5 mL
Collection Instructions:
1. If the volume is large, pellet cells prior to sending.
2. Send less volume at ambient temperature or as a frozen cell pellet.
Specimen Stability Information:
Body fluid: Ambient 4 days/Refrigerated/Frozen
Cell pellet: Frozen
Specimen Type: Paraffin-embedded bone marrow aspirate clot
Container/Tube: Paraffin block
Specimen Stability Information: Ambient
Specimen Type: Frozen tissue
Container/Tube: Plastic container
Specimen Volume: 100 mg
Collection Instructions: Freeze tissue within 1 hour of collection.
Specimen Stability Information: Frozen
Specimen Type: Paraffin-embedded tissue
Container/Tube: Paraffin block
Specimen Stability Information: Ambient
Specimen Type: Tissue
Slides: Unstained slides
Specimen Volume: 10 Slides
Specimen Stability Information: Ambient
Specimen Type: Spinal fluid
Container/Tube: Sterile vial
Specimen Volume: 5 to 10 mL
Specimen Stability Information: Ambient 4 days/Refrigerated
Specimen Type: Extracted DNA
Container/Tube: 1.5- to 2-mL tube
Specimen Volume: Entire specimen
Collection Instructions:
1. Label specimen as extracted DNA and source of specimen
2. Indicate volume and concentration of DNA on label
Specimen Stability Information: Refrigerated/Ambient
Specimen Minimum Volume
Body and spinal fluid: 1 mL
Tissue: 50 mg
Extracted DNA: 50 microliters (mcL) at 20 ng/mcL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Varies | ||
Special Instructions
Reference Values
An interpretive report will be provided.
Day(s) Performed
Monday through Friday
Test Classification
This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
81261-IGH (Immunoglobulin heavy chain locus) (eg, leukemias and lymphomas B-cell), gene rearrangement analysis to detect abnormal clonal populations; amplified methodology (eg. polymerase chain reaction)
81264-IGK (Immunoglobulin kappa light chain locus) (eg, leukemia and lymphoma, B-cell) gene rearrangement analysis, evaluation to detect abnormal clonal populations
81479 (if appropriate for government payers)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| BCGRV | Immunoglobulin Gene Rearrange, V | 61113-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| MP017 | Specimen: | 31208-2 |
| 19915 | Final Diagnosis: | 34574-4 |
| 608950 | Signing Pathologist | 19139-5 |
Report Available
7 to 14 daysReject Due To
| Bone marrow core biopsies Paraffin shavings |
Reject |
Method Name
Polymerase Chain Reaction (PCR)
Testing Algorithm
The following algorithms are available:
-Gastric MALT Lymphoma Diagnostic Algorithm     Â
Forms
1. Hematopathology Patient Information (T676)
2. If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.